The aim of this study was to determine the effects of the same day ART initiation on viral suppression; and identify predicators of viral suppression in the era of test and treat strategy.
A quantitative multicenter retrospective cohort study was conducted using routinely collected data in ART clinics during the initial and follow-up visits of clients in 18 public health facilities in Addis Ababa, Ethiopia. The same day initiation of antiretroviral treatment among PLHIV with age greater or equal to 15, regardless of their CD4 count can reduce morbidity, mortality, HIV transmission and eventually the incidence of new HIV infection. However, the effect of the same day ART
initiation on viral suppression remains contradicting.
The viral load suppression rate among the same day ART started was higher compared to those started ART after seven days, and is consistent with previous studies in other countries. TDF- based regimen, alive and on ART follow-up status, and working
functional status were predicators of viral suppression in this study. Strengthening the same day ART initiation with TDF based regimen is critical for prevention of HIV through viral suppression. Improving the quality of ART data is also essential to generate evidence and inform the practice.
Inhaltsverzeichnis (Table of Contents)
- Acknowledgement
- Table of Contents
- Abbreviations
- List of Tables
- List of Figures
- Abstract
- Introduction
- Research Objectives
- Methods
- Result
- Discussion
- Conclusion
- Recommendations
- References
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This thesis aims to investigate the effect of same-day initiation of antiretroviral treatment (ART) on viral load suppression among adults aged 15 years and older living with HIV in public health facilities in Addis Ababa. The study uses data collected from January 2017 to February 2021.
- Impact of Same-Day ART Initiation on Viral Load Suppression
- Sociodemographic and Clinical Characteristics Associated with Viral Suppression
- Effectiveness of ART Initiation Strategies in Addis Ababa
- Analysis of Viral Suppression Rates at 12 Months
- Factors Influencing Treatment Outcomes
Zusammenfassung der Kapitel (Chapter Summaries)
Introduction: This chapter provides background information on HIV/AIDS, the importance of ART, and the context of same-day ART initiation. It sets the stage for the research question by highlighting the global and local challenges and opportunities regarding HIV treatment and care. The chapter will likely include epidemiological data on HIV prevalence and treatment success rates in Addis Ababa. It also introduces the research problem and its significance, leading to the research objectives.
Research Objectives: This chapter clearly outlines the specific research aims and questions that guide the study. It details the specific hypotheses being tested, and the measurable outcomes that will demonstrate whether the hypotheses are supported or rejected. This will include specific objectives related to measuring the impact of same-day ART initiation on viral suppression, and identifying associated factors.
Methods: This section describes the research design and methodology employed in the study. This includes details on the study population, the sampling methods used to select participants, the data collection procedures (e.g., data extraction from electronic medical records), and the statistical analyses conducted to test the hypotheses and answer the research questions. It specifies which variables were analyzed and the chosen statistical techniques for evaluating associations between variables. The validity and reliability of the data and methods should be thoroughly addressed.
Result: This chapter presents the findings of the study. It reports the descriptive statistics on the socio-demographic and clinical characteristics of the study participants, including comparisons between the same-day and non-same-day ART initiation groups. It will present the main results related to viral suppression rates at 12 months, and includes tables and figures to visualize the data. The results will indicate the statistical significance of observed differences or associations.
Discussion: This section provides an interpretation of the study findings in relation to existing literature and the research objectives. It discusses the implications of the results, addressing any limitations of the study, and exploring the potential reasons for observed associations. This will include a comparison of findings to other studies of ART initiation and viral suppression, and suggestions for possible explanations of the observed effect of same-day ART initiation.
Schlüsselwörter (Keywords)
HIV, AIDS, Antiretroviral Treatment (ART), Viral Load Suppression, Same-Day ART Initiation, Addis Ababa, Ethiopia, Public Health, Viral Load, Treatment Outcomes, Sociodemographic Factors, Clinical Characteristics, Electronic Medical Records (EMR).
Frequently Asked Questions: Comprehensive Language Preview of a Thesis on Same-Day ART Initiation and Viral Load Suppression
What is the main topic of this thesis?
This thesis investigates the impact of same-day initiation of antiretroviral treatment (ART) on viral load suppression among adults with HIV in Addis Ababa, Ethiopia. It analyzes data collected between January 2017 and February 2021.
What are the key objectives of the research?
The study aims to determine the impact of same-day ART initiation on viral load suppression, identify sociodemographic and clinical factors associated with viral suppression, evaluate the effectiveness of ART initiation strategies in Addis Ababa, analyze viral suppression rates at 12 months, and pinpoint factors influencing treatment outcomes.
What are the key themes explored in the thesis?
Key themes include the effectiveness of same-day ART initiation, the influence of sociodemographic and clinical factors on viral suppression, the analysis of 12-month viral suppression rates, and the identification of factors affecting treatment success. The study also focuses on the context of HIV/AIDS treatment and care in Addis Ababa.
What is included in the "Chapter Summaries" section?
The "Chapter Summaries" section provides concise overviews of each chapter: the introduction (providing background on HIV/AIDS and ART), research objectives (detailing specific aims and hypotheses), methods (explaining the research design, data collection, and analysis), results (presenting the study findings), and discussion (interpreting the results and their implications).
What methods were used in this research?
The thesis details the research design, sampling methods (used to select participants), data collection procedures (likely involving data extraction from electronic medical records), and statistical analyses used to test hypotheses and answer research questions. The validity and reliability of the data and methods are also addressed.
What kind of results are presented in the thesis?
The results section presents descriptive statistics on the socio-demographic and clinical characteristics of participants, comparisons between same-day and non-same-day ART initiation groups, 12-month viral suppression rates, and the statistical significance of observed differences or associations. Tables and figures are used to visualize the data.
What is discussed in the "Discussion" chapter?
The discussion chapter interprets the study findings in relation to existing literature and research objectives. It addresses limitations of the study, explores reasons for observed associations, compares findings to other studies, and suggests explanations for the effect of same-day ART initiation.
What are the keywords associated with this thesis?
Keywords include HIV, AIDS, Antiretroviral Treatment (ART), Viral Load Suppression, Same-Day ART Initiation, Addis Ababa, Ethiopia, Public Health, Viral Load, Treatment Outcomes, Sociodemographic Factors, Clinical Characteristics, and Electronic Medical Records (EMR).
What is the overall structure of the thesis?
The thesis follows a standard structure including an acknowledgement, table of contents, abbreviations, lists of tables and figures, abstract, introduction, research objectives, methods, results, discussion, conclusion, recommendations, and references.
What is the target audience for this thesis?
The thesis is intended for academic use, allowing for the analysis of themes in a structured and professional manner.
- Arbeit zitieren
- Girma Birru (Autor:in), 2023, Effects of Same-Day ART initiation on Treatment Outcomes, München, GRIN Verlag, https://www.grin.com/document/1478159
