Leseprobe
Contents
Introduction
How many mutations are required to produce a human cancer cell?
Sequence data
Epidemiology
In vitro data
Histopathology
Is genetic instability necessary to acquire sufficient mutations?
The mutator phenotype hypothesis
Arguments which undermine the calculations’ assumptions
Clonal evolution and natural selection
Arguments for the calculations validity
Tissue Biology
Epigenetics
CpG island promoter hypermethylation
Global CpG hypomethylation
Does genetic instability accelerate tumour progression?
Cell clone ecology hypothesis
Mathematical assessment
Lab based test
Clinical data
Sequence Data
Implications for therapy
Conclusion
Bibliography
Ende der Leseprobe aus 35 Seiten
- Arbeit zitieren
- Pascal Kaufmann (Autor:in), 2011, How many mutations are required to produce a human cancer cell?, München, GRIN Verlag, https://www.grin.com/document/168293
Ähnliche Arbeiten
Kostenlos Autor werden
✕
Leseprobe aus
35
Seiten
Kommentare