For generations, the central nervous system (CNS) was regarded as an immunologically privileged sanctuary, securely walled off from the metabolic and inflammatory turbulence of the periphery. Modern neuroimmunology has thoroughly reshaped this perspective, revealing that systemic low-grade inflammation acts as a potent driving force behind chronic neurodegeneration. This research paper explores the deep mechanistic links connecting systemic blood inflammation to the onset and acceleration of Alzheimer’s disease (AD) and Parkinson’s disease (PD). By examining neurovascular unit breakdown, cellular infiltration, vagal signaling, and microglial priming, we elucidate how peripheral pathology fuels central proteinopathies, establishing a continuous, human centered narrative of systemic brain health.
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- Kunal Kunal (Autor:in), 2026, Unifying Peripheral Inflammation and Neurodegeneration Across Alzheimer’s and Parkinson’s Diseases, München, GRIN Verlag, https://www.grin.com/document/1774739
