Cancer being a complex disease is well implicated to deregulated activity of numerous cellular proteins ultimately accounting for functions of cell division and survival etc.Molecular oncological evidences point microtubules and their associated proteins called MAPs as one of the most vital proteins to elicit tumour malignancy at the cellular level.In this dissertation, a MAP protein called HPIP has been investigated for its role in polymerization of cytoskeleton, microtubules and cancer disease progression.Preliminary lines of experiment conducted under in vitro conditions enabled us to interpret HPIP as a factor promoting the polymerization of microtubules, the head apparatus for chromosomal congression and segregation during real time cell division.
Inhaltsverzeichnis (Table of Contents)
- Aim of the study
- Introduction
- Materials and Methods
- Results
- Discussion
- References
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
The project work aims to investigate the functional activity of HPIP protein on microtubule dynamics under in vitro conditions. The study seeks to explore the relationship between HPIP, a protein known to regulate estrogen receptor (ER) signaling, and microtubule dynamics.
- Estrogen receptor (ER) signaling and its role in cancer
- Microtubule dynamics and their influence on cellular processes
- HPIP protein and its function in regulating ER signaling
- The interplay between HPIP and microtubules
- The potential of HPIP as a target for cancer therapy
Zusammenfassung der Kapitel (Chapter Summaries)
- Aim of the study: This chapter outlines the primary objective of the study, which is to characterize the functional activity of HPIP protein on microtubule dynamics under in vitro conditions.
- Introduction: The introduction provides background information on estrogen receptor (ER) signaling, microtubule dynamics, and HPIP protein. It discusses the relevance of these elements in cancer development and the potential for HPIP to modulate ER signaling pathways.
- Materials and Methods: This chapter details the experimental procedures employed in the study, including the specific materials used and the methods for analyzing microtubule dynamics and the activity of HPIP.
- Results: This chapter presents the findings of the experimental work, describing the observed effects of HPIP on microtubule dynamics and providing insights into its functional activity.
Schlüsselwörter (Keywords)
Key terms relevant to the study include estrogen receptor (ER), microtubule dynamics, HPIP protein, cell signaling, cancer, in vitro, functional activity, and oncogenesis.
What is the role of HPIP in cancer progression?
HPIP is a MAP (microtubule-associated protein) that has been investigated for its role in promoting microtubule polymerization, which is linked to tumor malignancy.
How does HPIP affect microtubule dynamics?
Preliminary in vitro experiments suggest that HPIP acts as a factor that promotes the polymerization of microtubules during cell division.
What is the connection between HPIP and the Estrogen Receptor Alpha?
HPIP is a cytoplasmic regulator of ER-Alpha, meaning it modulates estrogen receptor signaling pathways which are crucial in cancer development.
Why are microtubules important in oncology?
Microtubules are vital for chromosomal segregation during cell division; deregulated microtubule activity is a hallmark of cancer cell survival and spread.
Could HPIP be a target for cancer therapy?
The dissertation explores HPIP’s functional activity, suggesting its potential relevance as a target due to its influence on cytoskeleton dynamics and oncogenesis.
