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Microglia in Neurodegenerative Diseases

Role of TTP in classical and alternative microglia activation pathway

Title: Microglia in Neurodegenerative Diseases

Internship Report , 2012 , 12 Pages , Grade: 1,0

Autor:in: Simon Schwörer (Author)

Medicine - Neurology, Psychiatry, Addiction
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Summary Excerpt Details

Microglia activation plays a crucial role in neurodegenerative diseases. There are at least two distinct ways of microglia activation, the classical lipopolysaccharide (LPS) induced pathway leading to secretion of pro-inflammatory cytokines and inflammation as well as the alternative interleukin-4 (IL-4) induced pathway resulting in increased wound healing and tissue repair (Figure 1). It is known that the anti-inflammatory alternative pathway is competent to dampen the inflammatory effects of the classical microglia activation, as IL-6 and tumor necrosis factor-α (TNF-α) levels of LPS-stimulated microglia were remarkably reduced after additional excitation of the alternative activation of microglia. This effect could be achieved by the use of particular RNA binding proteins. An example for such RNA binding proteins would be tristetraprolin (TTP). TTP is binding to AU-rich elements (ARE) in the 3’ untranslated region of mRNA molecules and promotes decay of ARE-containing transcripts by directing them to the exosome for rapid mRNA degradation. The aim of the practical research course was to ascertain a possible participation of TTP in the IL-4 induced alternative activation of microglia, thereby potentially explaining the dampening effect on the inflammatory pathway.

Excerpt


Inhaltsverzeichnis (Table of Contents)

  • Introduction
    • Classical and alternative activation pathways in microglia
    • Post-transcriptional control of cytokine production by TTP
    • Aim of the research
    • AMPK and TTP
  • Methods
    • Western Blot Analysis (WB)
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Details

Title
Microglia in Neurodegenerative Diseases
Subtitle
Role of TTP in classical and alternative microglia activation pathway
College
University of Ulm  (Experimentelle Neurologie)
Grade
1,0
Author
Simon Schwörer (Author)
Publication Year
2012
Pages
12
Catalog Number
V190962
ISBN (eBook)
9783656158493
ISBN (Book)
9783656158615
Language
English
Tags
microglia neurodegenerative diseases role
Product Safety
GRIN Publishing GmbH
Quote paper
Simon Schwörer (Author), 2012, Microglia in Neurodegenerative Diseases, Munich, GRIN Verlag, https://www.grin.com/document/190962
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