Study on Synthesis of 6-phenyl-4-(4-(4-(p-tolyolxy) phenoxy) phenyl)-5, 6-dinydropyridinmin-2(H)-one and their Antimicrobial Activity


Research Paper (postgraduate), 2013
8 Pages

Excerpt

INTRODUCTION

Chalcone (1) are the compounds were aromatic substitutes are introduced in to the terminal position of system C═C-C═, So chalcone are characterized by their position of a Ar(A)-CO-CH ═ CH-Ar(B) Structure in which two aromatic ring are linked by an aliphatic three carbon chain, thus chalcones are phenyl-styryl ketones containing reactive ketoethylenic group –C-CO═CH- .

Chalcones are also known as benzalacetophomes or benzylidene actophenones. chalcones are colored compounds because of presence of chromophore auxochromes. Chalcones are the precursors in the biosynthesis of anthocuanins and flavones.

Chalcones and substituted chalcones can be synthesized in laboratory by calisen-schmidt condensation of acetophenone or substituted acetophenone with aldehyde.

The first condensation was reported by kestanecki (2, 3) and he gave the name “Chalcones”. some substituted chalcones and their derivatives have been reported to process some interesting biological properties such as antibacterial, antifungal, insecticidal ,anesthetic, analgesic ,

Ulcerogenic .etc

The replacement of two –CH units in benzene by nitrogen atoms gives pyrimidines.Some substituted pyrimidines and their derivatives have been reported to possess antimicrobial, antitumour and antifungal (4-8) activities.

All these observation and the essential role of heterocyclic chalcones derivatives, pyrazolline depravities, and pyrimidines derivatives in the certain biological reaction encourage us to synthesis all these heterocyclic derivatives.

All effort are done in the research is to synthesized a novel compound that can be used for formulation of anticancer drugs.

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Details

Title
Study on Synthesis of 6-phenyl-4-(4-(4-(p-tolyolxy) phenoxy) phenyl)-5, 6-dinydropyridinmin-2(H)-one and their Antimicrobial Activity
Course
DOCTOR OF PHILOSOPHY IN CHEMISTRY
Authors
Year
2013
Pages
8
Catalog Number
V207809
ISBN (eBook)
9783656363866
File size
504 KB
Language
English
Tags
study, synthesis, antimicrobial, activity
Quote paper
Dr. Rajarshi Patel (Author)Hitesh Dave (Author)K. S. Nimavat (Author)K. B. Vyas (Author)P. V. Patel (Author), 2013, Study on Synthesis of 6-phenyl-4-(4-(4-(p-tolyolxy) phenoxy) phenyl)-5, 6-dinydropyridinmin-2(H)-one and their Antimicrobial Activity, Munich, GRIN Verlag, https://www.grin.com/document/207809

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Title: Study on Synthesis of 6-phenyl-4-(4-(4-(p-tolyolxy) phenoxy) phenyl)-5, 6-dinydropyridinmin-2(H)-one and their Antimicrobial Activity


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