The objective of this study was to determine the frequency of growth retardation in children with moderate to severe atopic dermatitis.
Forty children with atopic dermatitis fulfilling the inclusion criteria were entered in the study. Their height was recorded and growth charts were selected according to the age and gender of the patients. The results show growth retardation in children with atopic dermatitis. The frequency of the growth impairment was relatively more in severe disease and among girls, as depicted by growth charts.
Table of Contents
1. INTRODUCTION
2. REVIEW OF LITERATURE
2.1 ATOPIC DERMATITIS
2.2 EPIDEMIOLOGY
2.3 ETIOLOGY AND PATHOGENESIS
2.4 EXACERBATING FACTORS FOR ATOPIC DERMATITIS
2.5 HISTOPATHOLOGY OF ATOPIC DERMATITIS
2.6 DIAGNOSIS OF ATOPIC DERMATITIS
2.7 DIFFERENTIAL DIAGNOSIS OF ATOPIC DERMATITIS
2.8 COMPLICATIONS OF ATOPIC DERMATITIS
2.9 GROWTH IMPAIRMENT
2.10 ASSESSMENT OF GROWTH
3. OBJECTIVE
4. OPERATIONAL DEFINITIONS
4.1 ATOPIC DERMATITIS
4.2 SEVERITY
4.3 GROWTH RETARDATION
5. MATERIAL AND METHODS
5.1 SETTING
5.2 DURATION OF STUDY
5.3 SAMPLE SIZE
5.4 SAMPLING TECHNIQUE
5.5 STUDY DESIGN
5.6 SAMPLE SELECTION
5.7 DATA ANALYSIS
6. FREQUENCY OF GROWTH RETARDATION IN CHILDREN WITH MODERATE TO SEVERE ATOPIC DERMATITIS
7. RESULTS
8. DISCUSSION
9. CONCLUSION
Research Objectives & Key Themes
The primary objective of this study is to determine the frequency and prevalence of growth retardation among pediatric patients suffering from moderate to severe atopic dermatitis, evaluating potential clinical correlations between disease severity and physical development.
- Prevalence of growth retardation in children with atopic dermatitis
- Impact of disease severity on physical growth metrics
- Analysis of growth hormone and physiological factors in atopic children
- Clinical assessment methods using NCHS growth charts
- Gender-based differences in growth patterns among affected pediatric patients
Excerpt from the Book
PATHOGENESIS OF GROWTH RETARDATION IN ATOPIC DERMATITIS
One of the complications associated with atopic dermatitis is growth impairment in affected children, which may be attributed to following factors: Decreased nocturnal growth hormone release, Dysregulation of prostaglandin E2, Hypoproteinemia, Food allergy and unnecessary dietary restriction, Coexisting asthma, Corticosteroid therapy, Severity of disease.
GH is secreted from anterior pituitary. It is a major determinant of growth and metabolism and mediates its effects on target cells primarily by IGF-I, that is secreted from the liver and other tissues in response to growth hormone. IGF-I acts via activation of the IGF-I receptor. This receptor is widely distributed, which enables it to coordinate balanced growth among multiple tissues and organs, stimulating proliferation and differentiation of chondrocytes, myoblasts and protein synthesis. Deficiency in GH or defects in its binding to receptor are clinically manifested by growth retardation or dwarfism.
Secretion of GH is affected by many factors, including stress, exercise, nutrition and sleep. Growth hormone secretion is also controlled by various hormones, such as growth hormone-releasing hormone (GHRH), a hypothalamic peptide and ghrelin from the stomach, stimulates its secretion, while somatostatin inhibits growth hormone release. GH is mainly secreted at night, shortly after the onset of deep sleep.
Summary of Chapters
INTRODUCTION: Provides an overview of atopic dermatitis as a chronic skin disorder and introduces the clinical concern regarding its association with growth impairment in children.
REVIEW OF LITERATURE: Details the pathogenesis, epidemiology, and diagnostic criteria of atopic dermatitis, alongside the current understanding of growth physiology and potential causes of retardation.
OBJECTIVE: Defines the specific research aim: determining the frequency of growth retardation in children with moderate to severe atopic dermatitis.
OPERATIONAL DEFINITIONS: Establishes standardized criteria for classifying atopic dermatitis, disease severity using the SCORAD index, and the threshold for growth retardation.
MATERIAL AND METHODS: Describes the cross-sectional survey design conducted at WAPDA Hospital, including participant inclusion criteria and the analytical methods used for data collection.
RESULTS: Presents the primary findings, demonstrating that 37.5% of the enrolled 40 patients exhibited growth retardation, with higher frequency in severe cases.
DISCUSSION: Compares the study results with existing literature, highlighting the roles of disease severity, protein loss, and potential cultural factors on the growth of affected children.
CONCLUSION: Confirms that growth retardation is a significant concern in children with atopic dermatitis, particularly in those with severe disease and among female patients.
Keywords
Atopic dermatitis, Growth retardation, Growth chart, Pediatric dermatology, SCORAD index, Growth hormone, Prostaglandin E2, Nutritional status, Lahore, Pakistan, Physical development, Chronic inflammation, Skin barrier function, Childhood eczema, Clinical research
Frequently Asked Questions
What is the core focus of this research study?
The study primarily investigates the association between atopic dermatitis and physical growth, specifically aiming to quantify how frequently children with moderate to severe forms of the disease experience growth retardation.
What are the central themes discussed in the work?
The key themes include the clinical pathophysiology of atopic dermatitis, the physiological mechanisms regulating human growth, and the various environmental and organic factors, such as steroid use or dietary restrictions, that contribute to growth failure.
What is the primary research question?
The research asks: "What is the frequency of growth retardation in children diagnosed with moderate to severe atopic dermatitis?"
Which scientific methods were employed to conduct this study?
The study utilized a cross-sectional survey design, enrolling 40 pediatric patients, and applied anthropometric measurements plotted against NCHS growth charts, with data analyzed using SPSS software.
What does the main body of the paper cover?
The main body covers the literature review on atopic dermatitis and growth physiology, operational definitions, material and methods, results derived from demographic and growth chart analysis, and a comprehensive discussion on the findings.
Which keywords best characterize this publication?
The work is characterized by terms such as atopic dermatitis, growth retardation, growth charts, pediatric development, and disease severity.
How is the severity of atopic dermatitis classified in this study?
Severity is classified using the objective SCORAD index, where scores between 15-40 indicate moderate disease, and scores greater than 40 indicate severe disease.
Does the study identify any gender-specific differences?
Yes, the study observed that the frequency of growth retardation was relatively higher among female patients compared to male patients within the studied cohort.
- Arbeit zitieren
- Anjum Hashmi (Autor:in), Fayaz Mamluh Alazmi (Autor:in), Shahid Hashmi (Autor:in), 2016, Growth retardation in children with Atopic Dermatitis, München, GRIN Verlag, https://www.grin.com/document/340946
