Herbal medicines formulations are used to alleviate many types of diseases in the recent world. Because of the similar properties and the combination of the ingredients synergistically increase the efficacy, Nigella sativa (family-Ranunculaceae), Apis mellifera (family-Apidae) and Olea europaea (family-Oleaceae) were collected from the market for preparing an herbal product in a suitable solid dosage form preferably tablet. First time tried to prepare a tablet dosage form but it did not satisfy the parameter of a standard tablet dosage form due to oil containing ingredients and technical error. Then choose to prepare capsule dosage form with granules by using zero size capsule shell (#0) & eventually prepared successful herbal capsules. The most important challenges faced by herbal formulations arise because of their lack of complete evaluation. Moreover, for evaluation of capsule containing multiple herb, various parameters were tested such as organoleptic parameters, ash value etc & for finished product (capsule) include uniformity of weight, pH, disintegration time and effect of temperature & humidity of the product and all test accomplished the satisfactory results with the standard specifications.
Table of Contents
1 Chapter-I: Introduction
2 Chapter-II : Literature review
2.1 General literature review of herbal preparations
a Herbal history
b WHO definitions related to Herbal medicine
c Types of herbal medicine systems
d Biological background of herbal medicine
e Role of herbal medicine in modern human society
f Contribution of herbal drugs and development of herbal drug
g Effectiveness of herbal medicine
h Herbal medicine risks to health
i Adverse effect of herbs and drug herbal interaction
j Limitation of herbal medicine
k Comparison between herbal medicine and conventional medicine
2.2 Literature review of Herbs used in my present work
2.2.1 Black Cumin Seeds
a History of Black cumin seeds
b Description of Black cumin seeds
c Origin & distribution of Black cumin seeds
d Chemical constituents of Black cumin seeds
e Nutrition of Black cumin seeds
f Medicinal uses of Black cumin seeds
g Biological uses of Black cumin seeds
h Side Effects of Black cumin seeds
i Adverse effect of Black cumin seeds
2.2.2 Honey
a History of Honey
b Description of Honey
c Origin and distribution of Honey
d Chemical constituents of Honey
e Nutrients of Honey
f Medicinal uses of Honey
g Biological uses of Honey
h Side Effects of Honey
i Adverse effects of Honey
2.2.3 Jaitun Oil
a History of Jaitun oil
b Description of Jaitun oil
c Origin & distribution of Jaitun oil
d Chemical Constituent of Jaitun oil
e Nutrition of Jaitun oil
f Medicinal uses of Jaitun oil
g Biological uses of Jaitun oil
h Side effects of Jaitun oil
i Adverse effects of aitun oil
2.3 Quality Control of Herbal Drug
a Parameters for quality control of herbal drugs
b WHO guidelines for quality standardized herbal formulations
2.4 Objective of the work
2.5 Research protocol
3 Chapter-III : Materials-method with result and discussion
3.1 Materials
3.2 Tablet
3.3 Capsule
3.4 Method of evaluation of quality control parameters for raw materials
3.5 Method of evaluation of quality control parameters for finished product
4 Chapter-IV : Conclusion
Aims and Topics
This work explores how black cumin, honey and jaitun oil can be combined in a solid dosage form. It aims to develop a tablet or capsule and assess selected physical and chemical quality parameters of the resulting preparation.
- Herbal medicine history, definitions and safety
- Black cumin, honey and jaitun oil as formulation ingredients
- Tablet preparation and capsule filling
- Quality assessment of raw materials and finished capsules
- Disintegration and storage stability testing
Excerpt from the Book
Herbal history
In the written record, the study of herbs dates back over 5,000 years to the Sumerians, who described well-established medicinal uses for such plants as laurel, caraway, and thyme. Ancient Egyptian medicine of 1000 B.C. are known to have used garlic, opium, castor oil, coriander, mint, indigo, and other herbs for medicine and the Old Testament also mentions herb use and cultivation, including mandrake, vetch, caraway, wheat, barley, and rye.
Indian Ayurveda medicine has been using herbs such as turmeric possibly as early as 1900 B.C. Many other herbs and minerals used in Ayurveda were later described by ancient Indian herbalists such as Charaka and Sushruta during the 1st millennium BC. The Sushruta Samhita attributed to Sushruta in the 6th century BC describes 700 medicinal plants, 64 preparations from mineral sources, and 57 preparations based on animal sources.
The first Chinese herbal book, the Shennong Bencao Jing, compiled during the Han Dynasty but dating back to a much earlier date, possibly 2700 B.C., lists 365 medicinal plants and their uses - including ma-Huang, the shrub that introduced the drug ephedrine to modern medicine. Succeeding generations augmented on the Shennong Bencao Jing, as in the Yaoxing Lun (Treatise on the Nature of Medicinal Herbs), a 7th century Tang Dynasty treatise on herbal medicine.
The ancient Greeks and Romans made medicinal use of plants. Greek and Roman medicinal practices, as preserved in the writings of Hippocates and - especially - Galen, provided the patterns for later western medicine. Hippocrates advocated the use of a few simple herbal drugs - along with fresh air, rest, and proper diet. Galen, on the other hand, recommended large doses of drug mixtures - including plant, animal, and mineral ingredients. The Greek physician compiled the first European treatise on the properties and uses of medicinal plants, De Materia Medica. In the first century AD, Dioscorides wrote a compendium of more than 500 plants that remained an authoritative reference into the 17th century. Similarly important for herbalists and botanists of later centuries was the Greek book that founded the science of botany, Theophrastus’ Historia Plantarum, written in the fourth century B.C.
Chapter Summaries
Chapter-I: Introduction: Introduces herbal medicine, its historical use and the holistic perspective associated with traditional medical systems.
Chapter-II : Literature review: Reviews herbal medicine and the three selected ingredients, including their reported properties and risks. It also discusses quality control, the study objective and research protocol.
Chapter-III : Materials-method with result and discussion: Describes the materials, tablet and capsule formulations, manufacturing steps and tests on raw materials and finished capsules.
Chapter-IV : Conclusion: Brings together the formulation and quality evaluation and discusses the observations from stability testing.
Keywords
herbal medicine, solid dosage form, black cumin, Nigella sativa, honey, jaitun oil, olive oil, tablet formulation, capsules, wet granulation, quality control, disintegration, stability testing
Frequently Asked Questions
What is this work about?
It examines the preparation and evaluation of a solid dosage form combining black cumin, honey and jaitun oil.
What are the main topics?
The work covers herbal medicine, the selected ingredients, formulation methods and quality control of raw materials and capsules.
What is the main objective?
The objective is to design a combined herbal solid dosage form and assess it using selected quality parameters.
What research method is used?
The authors combine a literature review with laboratory formulation and physical and chemical evaluation.
What does the main body examine?
It presents tablet and capsule formulations, manufacturing procedures, raw-material tests and finished-product evaluations.
Which keywords characterize the work?
Key terms include black cumin, honey, jaitun oil, solid dosage form, capsules, quality control and stability testing.
Which ingredients are combined in the formulation?
The preparation combines black cumin seeds, honey and jaitun oil, also known as olive oil.
How are the finished capsules evaluated?
The reported tests include weight variation, disintegration time, pH and stability under different storage conditions.
Is another product used for comparison?
The study compares the disintegration time of its prepared herbal capsule with a marketed Nigella capsule.
- Quote paper
- Master of Pharmacy Sharmin Akhter (Author), Prof. M. Mohi Uddin Chowdhury (Author), Mohammed Ibrahim (Author), 2010, Preparation of Herbal Solid Dosage Form, Munich, GRIN Verlag, https://www.grin.com/document/377773
