In the present study, the gastroprotective mechanism of aqueous extract of Piper nigrum and Ferula foetida (AEPF) was investigated.
The current knowledge is clearly incontestable that AEPF pent-up the aggressive issue, gastric acid secretion. The anti-ulcerogenic impact of the AEPF is also associated with its antisecretory action since acid may be a major consideration the event of ulceration. The current data also clearly demonstrated that the 400 mg/kg is more effective than the 200 mg/kg and 100mg/kg dose of AEPF and has shown increased pH and decreased total acidity of gastric fluid. The ulcerogenic effect of cysteamine-induced duodenal ulcers was developed in rats that received cysteamine HCl 400mg/kg. The exact mechanism of pathological process within the cysteamine-induced peptic ulcer model isn't totally known however but hypersecretion of gastric acid, deterioration of mucosal resistance and promotion of gastric emptying are among the possible mechanisms. In cold restraint stress induced ulcer model blood parameters such as Glucose, cholesterol and Triglycerides were estimated.
The significant increase in blood sugar level was discovered because; beneath nerve-racking conditions, ductless gland secretes corticosterone in man and glucocorticoid in rats. AEPF significantly reduced the elevated serum cholesterol and triglycerides levels, which may be due to inhibition of stimulation of the sympathetic nervous system. Therefore it could act as a potent therapeutic agent against peptic ulcer disease.
Inhaltsverzeichnis (Table of Contents)
- Introduction
- Review of Literature
- Plant Review
- Aim and Objectives
- Materials and Methods
- Results
- Discussion
- Conclusion
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This study investigates the anti-secretory effects and gastroprotective properties of Piper nigrum and Ferula foetida in rats with peptic ulcers. The research aims to determine the efficacy of these plants in reducing gastric acid secretion and protecting the gastric mucosa from ulceration.
- Anti-secretory effects of Piper nigrum and Ferula foetida
- Gastroprotective effects of Piper nigrum and Ferula foetida
- Peptic ulcer pathogenesis and treatment
- Evaluation of traditional medicinal plants for therapeutic applications
- Assessment of the effects on gastric mucosal integrity and blood parameters
Zusammenfassung der Kapitel (Chapter Summaries)
- Chapter 1: Introduction provides a comprehensive overview of peptic ulcers, their pathogenesis, and the current treatment options. It highlights the need for new, effective, and safe therapies, particularly from natural sources.
- Chapter 2: Review of Literature delves into the historical and scientific evidence supporting the medicinal properties of Piper nigrum and Ferula foetida. This chapter explores the phytochemical constituents and pharmacological actions of these plants, including their anti-secretory and gastroprotective potential.
- Chapter 3: Aim and Objectives clearly define the research goals. It outlines the specific questions to be answered concerning the efficacy and mechanisms of action of Piper nigrum and Ferula foetida in treating peptic ulcers in rats.
- Chapter 4: Materials and Methods describes the experimental design, including the animal model, drug preparation, and procedures for inducing and evaluating peptic ulcers. It also explains the methods used to assess the effects of the plant extracts on gastric acid secretion, mucosal integrity, and blood parameters.
- Chapter 5: Results presents the findings of the study. It includes detailed data analysis and statistical comparisons of the effects of Piper nigrum and Ferula foetida on gastric ulcer indices, blood parameters, and other relevant markers.
Schlüsselwörter (Keywords)
The key concepts of this study include peptic ulcers, gastroprotection, Piper nigrum, Ferula foetida, anti-secretory effects, gastric acid secretion, gastric mucosa, animal models, pharmacological studies, traditional medicine, and natural products.
- Quote paper
- Balakrishna Vuyyala (Author), 2014, On the Effect of "Piper nigrum" and "Ferula foetida", Munich, GRIN Verlag, https://www.grin.com/document/463178
