In the present study, the gastroprotective mechanism of aqueous extract of Piper nigrum and Ferula foetida (AEPF) was investigated.
The current knowledge is clearly incontestable that AEPF pent-up the aggressive issue, gastric acid secretion. The anti-ulcerogenic impact of the AEPF is also associated with its antisecretory action since acid may be a major consideration the event of ulceration. The current data also clearly demonstrated that the 400 mg/kg is more effective than the 200 mg/kg and 100mg/kg dose of AEPF and has shown increased pH and decreased total acidity of gastric fluid. The ulcerogenic effect of cysteamine-induced duodenal ulcers was developed in rats that received cysteamine HCl 400mg/kg. The exact mechanism of pathological process within the cysteamine-induced peptic ulcer model isn't totally known however but hypersecretion of gastric acid, deterioration of mucosal resistance and promotion of gastric emptying are among the possible mechanisms. In cold restraint stress induced ulcer model blood parameters such as Glucose, cholesterol and Triglycerides were estimated.
The significant increase in blood sugar level was discovered because; beneath nerve-racking conditions, ductless gland secretes corticosterone in man and glucocorticoid in rats. AEPF significantly reduced the elevated serum cholesterol and triglycerides levels, which may be due to inhibition of stimulation of the sympathetic nervous system. Therefore it could act as a potent therapeutic agent against peptic ulcer disease.
Table of Contents
1. Introduction
2. Review of Literature
2.1 Plant Review
3. Aim and Objectives
4. Materials and Methods
5. Results
5.1 Discussion
6. Conclusion
Research Objectives and Focus Areas
The primary goal of this research is to evaluate the anti-ulcerogenic efficacy of an aqueous extract derived from Piper nigrum and Ferula foetida (AEPF) in experimental rat models to validate its potential as a therapeutic agent for peptic ulcer disease.
- Phytochemical screening of the Piper nigrum and Ferula foetida extract.
- Evaluation of AEPF on aspirin plus pylorus ligation-induced gastric ulcers.
- Assessment of the extract's impact on cysteamine-induced duodenal ulceration.
- Investigation of anti-ulcer activity in cold restraint stress-induced gastric ulcer models.
- Analysis of biochemical markers (glucose, cholesterol, triglycerides) under stress conditions.
Excerpt from the Book
1.1. HERBAL PLANTS- SIGNIFICANCE:
The history of herbal medicine is as old as the human civilization. Human beings seem to be afflicted with additional diseases than the other animal species. Man sought to alleviate his suffering from injury and disease by taking advantage of plants growing around him. In the past, almost all the medicines used by man were from the plants.
India is one of the oldest, richest and most diverse cultural traditions associated with the use of medicinal plants 1. The World Health Organization (WHO) has recently outlined traditional drugs (including herbal drugs) as comprising therapeutic practices that are alive, typically for many years, before the development and spread of modern medicine and are still in use today 2, 3. Or, traditional medicine is the synthesis of therapeutic experience of generations of practicing physicians of indigenous systems of medicine. The traditional preparations comprise medicative plants, minerals, organic matter, etc. herbal medication represent solely those ancient medicines that primarily use medicative plant preparations for medical aid.
Herbal drugs remains the mainstay of regarding 75-80% of the planet population, principally within the developing countries, for primary health care due to higher cultural acceptableness, better compatibility with the body and lesser side effects. However, last few years have seen a major increase in their use in the developing world 3.
Herbal medicines also offer therapeutics for age-related disorders like memory loss, osteoporosis, immune disorders, etc. for which no modern medicine is available. India, despite its wealthy content, heritage for herbal medicines and large biodiversity has a dismal share of the world market due to export of crude extracts and drugs. Development of herbal based products has increased manifold in the past few years in all parts of the world and thus the present age is also referred to as ‘the age of herbal products 4.
Summary of Chapters
1. Introduction: This chapter outlines the historical and current significance of herbal medicine and defines the scope of research regarding peptic ulcers.
2. Review of Literature: This section provides a comprehensive botanical and pharmacological overview of Piper nigrum and Ferula foetida.
3. Aim and Objectives: This chapter details the specific research targets, including the preparation of plant extracts and the selection of experimental models.
4. Materials and Methods: This section describes the collection of plant materials, extraction procedures, animal study protocols, and biochemical estimation methods.
5. Results: This chapter presents the data from various ulcer models and discusses the findings related to the gastroprotective and metabolic effects of the extract.
6. Conclusion: The final chapter summarizes the research outcomes and confirms the significant anti-ulcer activity of the tested plant extract.
Keywords
Antisecretory activity, Piper nigrum, Ferula foetida, Immobilisation stress, Ulcer activity, Gastroprotection, Pharmacognosy, Herbal medicine, Peptic ulcer, Antioxidant, Phytochemical screening, Anti-ulcerogenic, Cysteamine, Aspirin, Rat models.
Frequently Asked Questions
What is the core focus of this research?
The research investigates the gastroprotective mechanisms and anti-ulcer activity of an aqueous extract from Piper nigrum and Ferula foetida.
What are the primary themes of the study?
The study centers on traditional medicine, pharmacology, gastroenterology, and the therapeutic potential of plant extracts in treating gastric and duodenal ulcers.
What is the main objective of the work?
The primary aim is to scientifically evaluate and validate the traditional usage of these plants in treating peptic ulcer disease using in vivo experimental models.
Which scientific methods are employed?
The study uses standard experimental models, including aspirin plus pylorus ligation, cysteamine-induced duodenal ulceration, and cold restraint stress-induced ulceration, alongside biochemical analysis.
What does the main body of the work cover?
The main body covers the literature review of the plants, detailed experimental methodologies, statistical analysis, and a discussion of the observed results regarding ulcer index and blood parameters.
Which keywords characterize this work?
Key terms include antisecretory activity, Piper nigrum, Ferula foetida, gastroprotection, pharmacological evaluation, and peptic ulcer models.
How was the anti-ulcer activity measured?
Activity was measured by observing the reduction in ulcer index and scores, as well as changes in gastric acidity and blood parameters in rats treated with the extract compared to controls.
Did the research assess blood parameters?
Yes, the study estimated serum glucose, cholesterol, and triglyceride levels in the cold restraint stress-induced ulcer model to determine metabolic impacts.
What were the findings regarding the extract doses?
The results demonstrated that the 400 mg/kg dose was generally more effective than the lower doses (100 mg/kg and 200 mg/kg) in providing gastroprotective effects.
Is the extract considered safe based on the study?
Yes, the acute toxicity study performed according to CPCSEA guidelines showed no signs of mortality or toxicity up to a dose of 2000 mg/kg.
- Quote paper
- Balakrishna Vuyyala (Author), 2014, On the Effect of "Piper nigrum" and "Ferula foetida", Munich, GRIN Verlag, https://www.grin.com/document/463178
