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Magnetic resonance imaging for initial diagnosis of sporadic Creutzfeldt Jakob disease

Case series and review

Title: Magnetic resonance imaging for initial diagnosis of sporadic Creutzfeldt Jakob disease

Scientific Study , 2019 , 33 Pages

Autor:in: Robert Vollmann (Author)

Medicine - Radiology, Nuclear Medicine
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Summary Excerpt Details

The aim of this case series is to show the reliability of magnetic resonance imaging (MRI) in the initial diagnosis of this disease and demonstrate its advantages compared to other modalities. We also compared our cases with other larger studies and give a review of literature to confirm our observations.

Sporadic Creutzfeldt–Jakob disease (sCJD) is a uniformly fatal neurodegenerative disorder caused by the accumulation of an abnormal form of the human prion protein in the brain. It typically presents as a rapidly progressive dementia (RPD). For a definitive diagnosis, brain biopsy or autopsy is required (definite CJD). Premortal diagnosed patients are called probable CJD according to the diagnostic criteria of Zerr et al. So this entity can be difficult to identify antemortem.

Excerpt


Inhaltsverzeichnis (Table of Contents)

  • Abstract
  • Introduction
  • Material and Methods
    • Case 1
    • Case 2
    • Case 3
    • Case 4
    • Case 5
    • Case 6
  • Results
  • Discussion
  • Conclusion
  • References

Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)

This case series aims to demonstrate the reliability of magnetic resonance imaging (MRI) in the initial diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD), comparing its efficacy to other diagnostic modalities. It also presents a review of relevant literature to support the findings.

  • The reliability of MRI in diagnosing sCJD.
  • The use of diffusion-weighted imaging (DWI) and ADC map in sCJD diagnosis.
  • The role of cerebrospinal fluid (CSF) analysis and electroencephalogram (EEG) in sCJD diagnosis.
  • The clinical presentation and diagnostic criteria for sCJD.
  • The different forms of CJD and the pathology of prion diseases.

Zusammenfassung der Kapitel (Chapter Summaries)

The abstract provides an overview of the study, highlighting the importance of MRI in the initial diagnosis of sCJD. The introduction discusses the different forms of CJD and the pathology of prion diseases, emphasizing the fatal prognosis and lack of treatment for this condition. The “Material and Methods” section describes the case series of six patients diagnosed with sCJD, outlining the diagnostic tools used in the study, including DWI, EEG, and CSF analysis. The results section presents the findings of the case series, focusing on the MRI findings and the role of other diagnostic tools.

Schlüsselwörter (Keywords)

Sporadic Creutzfeldt-Jakob disease, sCJD, magnetic resonance imaging, MRI, diffusion-weighted imaging, DWI, ADC map, cerebrospinal fluid, CSF, 14-3-3 protein, electroencephalogram, EEG, prion diseases, neurodegenerative disorder, rapid progressive dementia.

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Details

Title
Magnetic resonance imaging for initial diagnosis of sporadic Creutzfeldt Jakob disease
Subtitle
Case series and review
College
Medizinische Universität Graz  (Radiologie)
Author
Robert Vollmann (Author)
Publication Year
2019
Pages
33
Catalog Number
V486923
ISBN (eBook)
9783668989283
ISBN (Book)
9783668989290
Language
English
Tags
Radiology MRI neurodegenerative disease
Product Safety
GRIN Publishing GmbH
Quote paper
Robert Vollmann (Author), 2019, Magnetic resonance imaging for initial diagnosis of sporadic Creutzfeldt Jakob disease, Munich, GRIN Verlag, https://www.grin.com/document/486923
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