A new Schiff base of o-phenylenediamine and m-hydroxybenzaldehyde was synthesized by condensation reaction. The Schiff base and its metal complexes of Co(II) and Ni(II) were then characterized spectroscopically. The complexes were tested for their antimicrobial properties using six selected micro-organisms, viz: (1) Staphylococcus aereus, (2) Pseudomonas aeruginosa (3) Escherichia coli (4) Enterococcus faecalis (5) Klebsiella Pneumonia and (6) Candida albicans. Results showed important antimicrobial activities which are believed to be beneficial and could be applied safely in the treatment of infections caused by any of these bacteria.
Inhaltsverzeichnis (Table of Contents)
- INTRODUCTION
- EXPERIMENTAL METHODS
- Synthesis of Schiff Base Ligand and Metal Complexes
- Fourier Transform Infrared (FTIR) and UV/VIS Spectroscopy
- Antimicrobial Assay
- RESULTS AND DISCUSSION
- Infrared and UV/VIS Spectroscopy
- Zones of Inhibition and Minimum Inhibitory Concentration (MIC)
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This study investigates the antimicrobial properties of synthesized Schiff base metal complexes using spectroscopic techniques and biochemical assay. The research aims to explore the potential of these complexes as antimicrobial agents, potentially contributing to the development of novel drugs to combat antibiotic-resistant bacteria.
- Synthesis and characterization of Schiff base ligands and their metal complexes.
- Evaluation of the antimicrobial activity of the synthesized complexes against a range of bacteria and fungi.
- Investigation of the structure-activity relationships of the complexes.
- Exploration of the potential of these complexes as novel antimicrobial agents.
Zusammenfassung der Kapitel (Chapter Summaries)
- Introduction: This chapter introduces the concept of coordination compounds, their significance in biological systems, and the specific focus on Schiff base complexes. The chapter discusses the growing problem of antibiotic resistance and the need for research into new antimicrobial agents.
- Experimental Methods: This section details the procedures used for the synthesis of the Schiff base ligand and its metal complexes. It also describes the spectroscopic and antimicrobial assay methods employed in the study.
- Results and Discussion: This chapter presents the results of the spectroscopic analysis of the Schiff base ligand and its metal complexes. It also discusses the antimicrobial activity of the complexes, including the zones of inhibition and minimum inhibitory concentrations obtained.
Schlüsselwörter (Keywords)
Schiff base complexes, antimicrobial activity, coordination compounds, antibiotic resistance, spectroscopic characterization, minimum inhibitory concentration, zone of inhibition.
- Quote paper
- Chibuzo Nnyigide (Author), 2019, Antimicrobial Properties of some Synthesized Schiff Base Metal Complexes, Munich, GRIN Verlag, https://www.grin.com/document/494076
