Chronic Fatigue Syndrome (CFS), or Myalgic Encephalomyelitis, is a complex disorder characterized by persistent, unexplained fatigue and post-exertional malaise. Following the COVID-19 pandemic, similar symptom clusters have emerged in Post-COVID Syndrome, suggesting shared pathophysiological mechanisms involving immune dysregulation, neuroinflammation, mitochondrial dysfunction, and autonomic imbalance. Diagnosis is clinical and requires exclusion of alternative causes. Management focuses on individualized, multidisciplinary rehabilitation, integrating pharmacological symptom control, graded physical therapy, cognitive-behavioral and occupational interventions, and cognitive rehabilitation. Evidence supports modest improvements in fatigue, function, and quality of life through multimodal approaches. Early, coordinated intervention appears to enhance recovery trajectories. Further research into biological markers and mechanism-based therapies is essential to improve diagnostic precision and long-term outcomes in Post-COVID and CFS populations.
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- Tobias Giesen (Author), 2025, Chronic Fatigue Syndrome in the Context of Post-COVID. A Comprehensive Evidence-Based Review, Munich, GRIN Verlag, https://www.grin.com/document/1665576
