Platelet counts and its associated indices of MPV, PDW and P‐LCR were assayed in a total sample of 98 blood donors aged 19 to 55years here in Porto Novo. Among whom 47 were men(47.96%) and 51 were women (52.04%). The mean platelets count of 218.90 × 109/L were recorded among men samples while Platelet count of 247.8 × 109/L were recorded
among women blood donors. The platelet count were slightly higher in women than men and this increase is not statistically significant (P=0.01). The indices of platelets, MPV, PDW and P‐LCR were also variable among both men and women, again these are not
statistically significant (P=0.01).
Conclusion: The present study showed that platelet count are gender dependent and platelet indices should be paid attention to when diagnosing thrombocytopenia. The routine hematologic autoanalyzers should incorporate reticulated platelet absolutely necessary for the accurate assessment of marrow response to thrombocytopenia.

Excerpt

Aims and Objectives
Acknowledgement
Abstract
Introduction
Methodology
Result
Discussion
References

Objectives and Key Themes

Platelet count and its indices as diagnostic markers for thrombocytopenia.
Sex differences in platelet count and its associated indices.
Statistical significance of observed variations in platelet parameters between men and women.
The role of reticulated platelets in accurately assessing bone marrow response to thrombocytopenia.
Implications for routine hematological analysis and thrombocytopenia diagnosis.

Chapter Summaries

Aims and Objectives: This section outlines the study's primary goal: to examine platelet count, MPV, PDW, and P-LCR profiles as diagnostic indicators for thrombocytopenia and to determine whether sex differences exist in these parameters. It clearly states the research question and sets the stage for the investigation.

Abstract: The abstract summarizes the study's methodology, findings, and conclusions. Ninety-eight blood donors (47 men, 51 women) aged 19-55 were analyzed. While women showed slightly higher mean platelet counts than men, this difference wasn't statistically significant (P=0.01). Variations in MPV, PDW, and P-LCR were also observed, but lacked statistical significance. The study concludes that platelet counts are gender-dependent, and platelet indices are crucial when diagnosing thrombocytopenia. The inclusion of reticulated platelet count in routine hematological analysis is advocated for improved diagnostic accuracy.

Introduction: [This section is assumed but not included in the provided text. A summary would describe the background on platelet function and thrombocytopenia, the rationale for studying sex differences in platelet parameters, and a review of relevant previous research, leading to the statement of the research problem that the study aims to address.]

Methodology:[This section is assumed but not included in the provided text. A summary would detail the study design, participant selection criteria, data collection methods (blood sample collection and analysis techniques), statistical analysis methods employed to analyze the data, and the overall approach to ensure the validity and reliability of the research findings.]

Result: [This section is assumed but not included in the provided text. A summary would present the key findings from the statistical analysis of the platelet count and indices (MPV, PDW, P-LCR) in male and female participants. It would quantitatively describe the observed differences (or lack thereof) between the sexes and highlight any significant trends or patterns identified in the data.]

Discussion: [This section is assumed but not included in the provided text. A summary would interpret the results in light of the existing literature, discussing the implications of the findings for thrombocytopenia diagnosis and treatment. It would address any limitations of the study, suggest avenues for future research, and offer a reasoned and well-supported conclusion based on the evidence collected and analysed.]

Keywords

Platelet count, MPV, PDW, P-LCR, thrombocytopenia, sex differences, reticulated platelets, hematological analysis, diagnostic indices, bone marrow response.

Frequently Asked Questions: A Study on Platelet Count and Indices as Diagnostic Markers for Thrombocytopenia

What is the main objective of this study?

This study aimed to investigate platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR) as diagnostic indices for thrombocytopenia and to explore sex differences in these parameters. It sought to determine if these platelet indices could effectively differentiate between healthy individuals and those with thrombocytopenia, and whether there were statistically significant variations between men and women.

What key themes are explored in this study?

The key themes include the use of platelet count and its associated indices (MPV, PDW, P-LCR) as diagnostic markers for thrombocytopenia, the existence and significance of sex differences in these platelet parameters, and the potential role of reticulated platelets in improving diagnostic accuracy. The study also considers the implications of its findings for routine hematological analysis and thrombocytopenia diagnosis.

What is the methodology employed in this study?

While the detailed methodology is not explicitly provided in this preview, it is implied that the study involved analyzing blood samples from 98 blood donors (47 men and 51 women) aged 19-55. Specific data collection and statistical analysis methods are not detailed here, but they were employed to evaluate the relationship between platelet parameters and thrombocytopenia, as well as to compare these parameters between men and women.

What are the key findings of the study?

The preview indicates that while women showed slightly higher mean platelet counts than men, this difference was not statistically significant. Variations in MPV, PDW, and P-LCR were also observed, but these variations also lacked statistical significance according to the provided data. The study suggests that while platelet counts themselves may be gender-dependent, consideration of platelet indices is crucial for accurate diagnosis of thrombocytopenia. The inclusion of reticulated platelet count in routine hematological analysis is proposed to further improve diagnostic accuracy.

What are the implications of this study?

The findings suggest that platelet indices (MPV, PDW, P-LCR) are valuable in the diagnosis of thrombocytopenia, in addition to simple platelet counts. The study advocates for incorporating reticulated platelet counts into routine hematological analysis to enhance the accuracy of thrombocytopenia diagnosis. Further research is likely needed to fully explore the complexities of sex differences and the precise role of each platelet index.

What are the limitations of this study (as apparent from the preview)?

The preview lacks complete details on methodology and results. The precise statistical methods used are not described, limiting our ability to fully assess the validity and reliability of the findings. Furthermore, a complete discussion of limitations, such as sample size or potential confounding factors, is not included in the preview.

What are the keywords associated with this study?