Urinary tract infections are the most common bacterial infections globally, caused by Escherichia coli. Escherichia coli produces an enzyme called extended spectrum β-lactamases (ESBL) which inhibits penicillins, cephalosporins and various other antibiotics. The current study included 1720 specimens, isolated from urine samples of inpatients and outpatients suffering from Urinary tract infections. The antimicrobial susceptibility by disc diffusion was performed on each isolate by using 10 antibiotics according to Clinical Laboratory Standards Institute (CLSI) criteria. 370 (21.5%) specimens were confirmed to be E.coli isolates. E.coli isolates were found to be 97.2% sensitive against Imipenem, 96.4% against Meropenem, 50.0% against Gentamicin, 47.2% against Kanamycin, 38.3% against Ciprofloxacin, 15.6% against Doxycycline, and 25.6% sensitive against Co-trimoxazole. A large proportion of E.coli isolates were found to be multi drug resistant. E.coli isolates were found to be 91.8% resistant against Ampicillin, 84.3% against Doxycycline, 82.4% against Cefaclor, and 80.5% resistant against Nalidixic Acid.
Inhaltsverzeichnis (Table of Contents)
- Introduction
- Material and methods
- Bacterial isolates
- Antimicrobial susceptibility testing
- Statistical analysis
- Results
- Discussion
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This study investigates the prevalence of Escherichia coli (E. coli) in urinary tract infections (UTIs) in Mansehra, Pakistan, and evaluates the antimicrobial susceptibility patterns of these isolates. The objective is to contribute to efficient management of UTIs in the region by understanding the antibiotic resistance trends.
- Prevalence of E. coli in UTIs in Mansehra, Pakistan
- Antimicrobial susceptibility patterns of E. coli isolates
- Comparison of E. coli resistance to various antibiotics
- Factors contributing to antibiotic resistance
- Recommendations for effective UTI treatment and antibiotic stewardship
Zusammenfassung der Kapitel (Chapter Summaries)
The introduction provides background information on E. coli as a common UTI pathogen and the growing global concern of antimicrobial resistance. It highlights the importance of understanding E. coli susceptibility patterns for optimal UTI management. The "Material and methods" section describes the study design, including the collection of urine samples, bacterial isolation, and the antimicrobial susceptibility testing methodology. Results include a detailed analysis of the prevalence of E. coli isolates, demographic data of the patients, and the susceptibility patterns of E. coli to various antibiotics. The discussion interprets the findings, highlighting the significance of resistance patterns to certain antibiotics and comparing the results with other studies. It also emphasizes the need for effective antibiotic stewardship strategies to mitigate the increasing resistance to antibiotics.
Schlüsselwörter (Keywords)
Antimicrobial resistance, Escherichia coli, Extended Spectrum ß-Lactamase, Urinary Tract Infections, antibiotic stewardship, Pakistan, prevalence, susceptibility patterns.
- Citation du texte
- Islam Ud Din Khan (Auteur), 2013, Antimicrobial susceptibility patterns and proportions of Escherichia coli in urinary tract infections in Mansehra, Pakistan, Munich, GRIN Verlag, https://www.grin.com/document/265002
