To investigate the spectrum of organisms causing neonatal sepsis in Peshawar, Pakistan and to assess their sensitivity to various groups of drugs.
Methods: Blood taken from newborn babies admitted to the special care baby unit at the Khyber Teaching Hospital with a clinical diagnosis of neonatal sepsis was cultured. The data obtained from October 1997 to December 2000 were analysed and the results tabulated.
Results: A total of 1598 blood cultures were taken; 1003 were positive (positivity rate 62.8%).Escherichia coli was the most common organism found (36.6%), followed by Staphylococcus aureus (29.5%), Pseudomonas (22.4%), Klebsiella (7.6%), and Proteus (3.8%). No group B streptococcus was grown. Listeria monocytogenes was found in one cerebrospinal fluid culture. E coli and Pseudomonas showed a high degree of resistance to commonly used antibiotics (ampicillin, augmentin, and gentamicin), a moderate degree of resistance to cephalosporin (cefotaxime, ceftzidime, and ceftrioxone), and low resistance to drugs not used for newborn babies (ofloxacin, ciprofloxacin, and enoxabid). S aureus showed a low resistance to all three groups of antibiotics.
Conclusion: Neonatal sepsis remains one of the leading causes of neonatal admission, morbidity, and mortality in developing countries. Gram negative organisms are the major cause of neonatal sepsis in Peshawar. Such organisms have developed multidrug resistance, and management of patients infected with them is becoming a problem in developing countries.
Inhaltsverzeichnis (Table of Contents)
- Abstract
- Introduction
- MATERIALS AND METHODS
- RESULTS
- DISCUSSION
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
The primary objective of this research is to analyze the prevalence of organisms causing neonatal sepsis in Peshawar, Pakistan, and assess their susceptibility to various antibiotic groups. The study aims to identify the most common pathogens and understand their resistance patterns to commonly used antibiotics, particularly in the context of developing countries.
- Prevalence of neonatal sepsis in Peshawar, Pakistan
- Spectrum of organisms causing neonatal sepsis
- Antimicrobial resistance patterns of neonatal sepsis pathogens
- Impact of antibiotic resistance on neonatal sepsis management
- Comparison of resistance patterns with other developing countries
Zusammenfassung der Kapitel (Chapter Summaries)
The "Abstract" provides a concise overview of the study's goals, methods, results, and conclusions. It highlights the prevalence of Gram-negative organisms causing neonatal sepsis and their resistance to commonly used antibiotics. The "Introduction" discusses the global burden of neonatal sepsis, emphasizing the importance of understanding the changing spectrum of pathogens and the emergence of multidrug resistance. The "MATERIALS AND METHODS" section outlines the study design, patient population, sample collection, and antibiotic susceptibility testing methods. The "RESULTS" section presents the findings of the blood cultures, including the prevalence of different pathogens and their sensitivity patterns to various antibiotics. The "DISCUSSION" section analyzes the findings in the context of existing literature, highlighting the similarities and differences in pathogen prevalence and resistance patterns between Peshawar and other regions. It underscores the challenges posed by multidrug resistance and the need for prudent antibiotic use to address this growing concern.
Schlüsselwörter (Keywords)
The key focus topics of this study are neonatal sepsis, antimicrobial resistance, Gram-negative organisms, antibiotic susceptibility, developing countries, Pakistan, Peshawar, multidrug resistance, and prudent antibiotic use. This research emphasizes the need for understanding antibiotic resistance patterns and implementing strategies for effective management of neonatal sepsis, particularly in resource-limited settings.
- Quote paper
- Islam Ud Din Khan (Author), 2013, Antimicrobial resistance of organisms causing neonatal sepsis, Munich, GRIN Verlag, https://www.grin.com/document/266185
