Piper nigrum is one amongst the thousands of the plants which have been bestowed with rich medicinal values.The work has been done to explore the therapeutic potential of piperine from Piper nigrum and synthesize of some piperine analogues.
The work has been planned to carry out detailed phytochemical studies to isolate and characterize the main alkaloidal phytoconstituents i.e. piperine present in the methanolic extract. The basis of selection of piperine is its CNS depressant activity and to expect the synthesis of some potent CNS Depressants derived from piperine after isoloation.
Further, the piperine and its semi-synthetic analogues have been screened for its CNS Depressants activity.
Inhaltsverzeichnis (Table of Contents)
- INTRODUCTION
- NATURAL PRODUCT AND DRUG DISCOVERY
- SEMI-SYNTHETIC PATHWAY
- SELECTION OF RECEPTORS
- INTRODUCTION OF THE PLANT
- LITERATURE SURVEY
- SOURCES OF LITERATURE
- CHEMICAL INVESTIGATIONS
- PHARMACOLOGICAL INVESTIGATIONS
- MICROBIOLOGICAL INVESTIGATIONS
- SYNTHETIC INVESTIGATIONS
- RATIONALE, OBJECTIVES & PLAN OF WORK
- EXPERIMENTAL WORK
- PHYTOCHEMICAL STUDIES
- COMPUTATIONAL STUDIES
- SEMI-SYNTHETIC STUDIES
- PHARMACOLOGICAL STUDIES
- SUMMARY AND CONCLUSION
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This thesis explores the potential of semi-synthetic piperine analogs as central nervous system (CNS) depressants. The study aims to investigate the synthesis and pharmacological activity of these analogs, ultimately contributing to the development of novel therapeutic agents for CNS disorders.
- Natural product discovery and semi-synthetic drug development.
- The role of piperine analogs as CNS depressants.
- Pharmacological investigations of the synthesized analogs.
- Computational studies to assess the potential interactions of the analogs with specific receptors.
- Exploring the potential therapeutic applications of these analogs.
Zusammenfassung der Kapitel (Chapter Summaries)
The initial chapters provide a thorough introduction to the field of natural product drug discovery and the specific role of semi-synthetic pathways in developing new therapeutic agents. These chapters focus on the rationale for selecting piperine as a starting material and highlight the importance of understanding its pharmacological properties. The introduction also delves into the selection of relevant receptors for the study.
A comprehensive literature survey on piperine and its analogs follows, exploring various aspects of their chemical, pharmacological, and microbiological properties. The survey provides a solid foundation for understanding the current knowledge base and the rationale for further investigations.
The experimental work section details the methodology and findings of the study. The chapter covers various stages of the research, including phytochemical investigations, computational studies, semi-synthetic studies, and pharmacological studies. This section presents the results of the research, highlighting the key findings and advancements achieved. The final chapter will likely summarize the findings, draw conclusions, and outline potential future directions for research.
Schlüsselwörter (Keywords)
This thesis focuses on natural product drug discovery, semi-synthetic pathways, piperine analogs, CNS depressants, pharmacological investigations, computational studies, and therapeutic potential. Specific terms of interest include AMPA, GluR receptors, and NMDAR.
- Quote paper
- Dr. Manik Ghosh (Author), Dr. Barij Nayan Sinha (Author), Mushtari Akhter (Author), 2009, Studies on some semi-synthetic piperine analogous as Central Nervous System Depressants, Munich, GRIN Verlag, https://www.grin.com/document/293986
