Piper nigrum is one amongst the thousands of the plants which have been bestowed with rich medicinal values.The work has been done to explore the therapeutic potential of piperine from Piper nigrum and synthesize of some piperine analogues.
The work has been planned to carry out detailed phytochemical studies to isolate and characterize the main alkaloidal phytoconstituents i.e. piperine present in the methanolic extract. The basis of selection of piperine is its CNS depressant activity and to expect the synthesis of some potent CNS Depressants derived from piperine after isoloation.
Further, the piperine and its semi-synthetic analogues have been screened for its CNS Depressants activity.
Inhaltsverzeichnis (Table of Contents)
- 1. INTRODUCTION
- 1.1. NATURAL PRODUCT AND DRUG DISCOVERY
- 1.2. SEMI-SYNTHETIC PATHWAY
- 1.3. SELECTION OF RECEPTORS
- 1.4. INTRODUCTION OF THE PLANT
- 2. LITERATURE SURVEY
- 2.1. SOURCES OF LITERATURE
- 2.2. CHEMICAL INVESTIGATIONS
- 2.3. PHARMACOLOGICAL INVESTIGATIONS
- 2.4. MICROBIOLOGICAL INVESTIGATIONS
- 2.5. SYNTHETIC INVESTIGATIONS
- 3. RATIONALE, OBJECTIVES & PLAN OF WORK
- 4. EXPERIMENTAL WORK
- 4.1. PHYTOCHEMICAL STUDIES
- 4.2. COMPUTATIONAL STUDIES
- 4.3. SEMI-SYNTHETIC STUDIES
- 4.4. PHARMACOLOGICAL STUDIES
- 5. SUMMARY AND CONCLUSION
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This thesis aims to investigate semi-synthetic piperine analogs as potential central nervous system (CNS) depressants. The research explores the synthesis and pharmacological evaluation of these analogs, building upon existing literature on piperine and its biological activities.
- Exploration of semi-synthetic pathways for piperine analogs.
- Evaluation of the pharmacological properties of synthesized piperine analogs.
- Computational studies to predict and understand the activity of the analogs.
- Phytochemical studies of the natural source of piperine.
- Assessment of the potential of these analogs as CNS depressants.
Zusammenfassung der Kapitel (Chapter Summaries)
1. INTRODUCTION: This introductory chapter lays the groundwork for the thesis by discussing the importance of natural products in drug discovery and development, focusing on the semi-synthetic approach. It introduces piperine, highlighting its potential as a lead compound for CNS depressants, and details the selection of relevant receptors and the plant source from which piperine is derived. The chapter establishes the rationale and context for the subsequent experimental and analytical sections of the thesis.
2. LITERATURE SURVEY: This chapter comprehensively reviews existing literature relevant to piperine and its analogs. It covers chemical investigations detailing the structure and synthesis of piperine and related compounds; pharmacological investigations examining their biological activities and mechanisms of action; microbiological investigations concerning any antimicrobial properties; and finally, a summary of previous synthetic efforts to modify piperine's structure. This review serves to contextualize the current research within the broader scientific landscape.
3. RATIONALE, OBJECTIVES & PLAN OF WORK: This chapter outlines the research objectives, including the synthesis of novel piperine analogs and their subsequent pharmacological evaluation. It provides a concise plan for the experimental work, specifying the methodologies and analytical techniques to be employed throughout the study. This section serves as a roadmap, guiding the reader through the methodology employed in the subsequent experimental sections.
4. EXPERIMENTAL WORK: This chapter details the experimental procedures undertaken in the thesis. It encompasses phytochemical studies to characterize the natural source material; computational studies using molecular modeling techniques to predict the properties and activity of the synthesized analogs; semi-synthetic studies focusing on the synthesis of new piperine analogs using various chemical reactions; and finally, pharmacological studies to assess the CNS depressant activity of the synthesized compounds using appropriate in vitro or in vivo models. The chapter meticulously documents the experimental methodology and results.
Schlüsselwörter (Keywords)
Piperine, semi-synthetic analogs, central nervous system depressants, drug discovery, natural products, pharmacological activity, phytochemical studies, computational studies, synthesis, CNS receptors.
Frequently Asked Questions: A Comprehensive Language Preview of Semi-Synthetic Piperine Analogs as Potential CNS Depressants
What is the main focus of this thesis?
This thesis investigates semi-synthetic piperine analogs as potential central nervous system (CNS) depressants. It explores the synthesis, pharmacological evaluation, and computational modeling of these analogs, building on existing knowledge of piperine and its biological activities.
What are the key objectives of this research?
The key objectives include exploring semi-synthetic pathways for piperine analogs, evaluating their pharmacological properties, conducting computational studies to predict their activity, performing phytochemical studies of the natural piperine source, and assessing their potential as CNS depressants.
What are the key themes explored in this research?
Key themes include drug discovery from natural products, semi-synthetic approaches to drug development, CNS pharmacology, computational chemistry in drug design, and the phytochemistry of piperine's natural source.
What is the structure of the thesis?
The thesis is structured into five chapters: 1. Introduction (including natural product discovery, semi-synthetic pathways, receptor selection, and plant introduction); 2. Literature Survey (covering chemical, pharmacological, microbiological, and synthetic investigations); 3. Rationale, Objectives & Plan of Work; 4. Experimental Work (including phytochemical, computational, semi-synthetic, and pharmacological studies); and 5. Summary and Conclusion.
What types of studies are included in the experimental work?
The experimental work encompasses phytochemical studies to characterize the natural source material; computational studies using molecular modeling to predict analog properties and activity; semi-synthetic studies focusing on the synthesis of new piperine analogs; and pharmacological studies to assess the CNS depressant activity of the synthesized compounds.
What is the significance of the literature review?
The literature review comprehensively examines existing research on piperine and its analogs, covering chemical structure, synthesis, biological activities, mechanisms of action, antimicrobial properties, and previous synthetic modifications. This contextualizes the current research within the broader scientific landscape.
What is the role of computational studies in this research?
Computational studies utilize molecular modeling techniques to predict the properties and activity of the synthesized piperine analogs, aiding in the design and optimization of the synthesis process and ultimately improving the understanding of structure-activity relationships.
What are the key words associated with this research?
Key words include Piperine, semi-synthetic analogs, central nervous system depressants, drug discovery, natural products, pharmacological activity, phytochemical studies, computational studies, synthesis, and CNS receptors.
What is the overall conclusion of the thesis? (Note: This question cannot be fully answered from the provided preview.)
The provided preview does not contain the conclusion. The final chapter (Chapter 5) will summarize the findings and conclusions drawn from the research presented in the previous chapters.
- Citar trabajo
- Dr. Manik Ghosh (Autor), Dr. Barij Nayan Sinha (Autor), Mushtari Akhter (Autor), 2009, Studies on some semi-synthetic piperine analogous as Central Nervous System Depressants, Múnich, GRIN Verlag, https://www.grin.com/document/293986
