Propagation of hippocampal activity in ultra-high risk schizophrenia psychosis subjects using Independent Component Analysis

Table of Contents

Abstract

Introduction
Schizophrenia and Visual Working Memory
Ultra-High-Risk of psychosis
Ultra-High-Risk of psychosis and Visual Working Memory
Hippocampus and Visual Working Memory
Hippocampal Impairments in Schizophrenia
The P300 event related potential
P300 Impairments in Schizophrenia
The P300 as a putative biomarker of psychosis risk
Detecting hippocampal activity through scalp EEG
Rationale, Aims and Hypotheses

Methods
Participants
Pilot study sample
PSYSCAN study sample
Inclusion and exclusion criteria
Ethical considerations
Visual Working Memory Task (based on Hannula, 2015)
Design and Procedure
EEG Data Acquisition and analysis
ERP Processing
Statistical Analysis

Results
Pilot Study Analysis
Demographics
ERPs
Visual Analysis of EEG 3D Amplitude Maps
Power Analysis
PSYSCAN Study Analysis
Demographics
ERPs
Independent samples t-test
Visual Analysis of EEG 3D Amplitude Maps

Discussion
P300 ERP components in a visual working memory task
Mesial sources contribution to scalp EEG
Hippocampus activation and Visual Working Memory
P300 ERP in UHR subjects
Hippocampal activity detection in UHR subjects
Strengths of the current study
Limitations of the current study
Future directions

Conclusion

References

Appendices

APPENDIX A: Demographic information for all samples from pilot study and PSYSCAN study

APPENDIX B: P300 ERP-Waveform Amplitude and Latencies for Each Participant at channels PZ and FZ