Present pharmaceutical scenario is aimed at development of drug delivery systems which maximize the drug targeting along with high therapeutic benefits for safe and effective management of diseases.
Target drug delivery system indeed a very attractive goal because in this system targeting of an active bio molecule from effective drug delivery where pharmacological agents directed specifically to its target.
Various cellular carriers has been used for drug targeting among which cellular carriers(leukocytes, platelets and erythrocytes) offer a great potential.
Erythrocytes also known as red blood cells and have extensively studied for their potential carrier capabilities for delivery of drugs .
Table of Contents
- Introduction
- Source of erythrocytes
- Isolation of erythrocytes
- Drug loading in erythrocytes
- Factors effecting resealed erythrocytes
- Advantages of erythrocytes
- Method of drug loading
- In vitro characterization of erythrocytes
- Applications
Objectives and Key Themes
This text aims to explore the potential of erythrocytes as drug delivery vehicles. It examines the properties of erythrocytes, methods for drug loading, and factors influencing their effectiveness. The text also considers the advantages of using erythrocytes for drug delivery and outlines potential applications.
- Erythrocytes as drug delivery systems
- Methods of drug loading into erythrocytes
- Factors affecting the efficacy of erythrocyte-based drug delivery
- Advantages of using erythrocytes over other drug delivery methods
- Applications of erythrocyte-based drug delivery systems
Chapter Summaries
Introduction: This introductory chapter sets the stage by discussing the current pharmaceutical landscape and its focus on developing targeted drug delivery systems to enhance therapeutic benefits and disease management. It highlights the attractiveness of targeted drug delivery, where active biomolecules are directed to their specific targets. The chapter introduces erythrocytes as promising cellular carriers for drug targeting, emphasizing their extensive study and potential.
Source of erythrocytes: This section details the various mammalian sources of erythrocytes used in drug loading, resealing, and subsequent drug and enzyme delivery. Examples include erythrocytes from mice, cattle, pigs, dogs, sheep, goats, monkeys, chickens, rats, and rabbits. The chapter also mentions the use of anticoagulants such as EDTA or heparin in the process.
Keywords
Erythrocytes, red blood cells, drug delivery, targeted drug delivery, drug loading, resealing, mammalian erythrocytes, anticoagulants, in vitro characterization, applications.
Frequently Asked Questions: Erythrocyte-Based Drug Delivery Systems
What is the main topic of this text?
This text comprehensively explores the use of erythrocytes (red blood cells) as vehicles for targeted drug delivery. It covers various aspects, from the source and isolation of erythrocytes to methods of drug loading, factors influencing effectiveness, advantages over other methods, and potential applications.
What are the key themes discussed in the text?
Key themes include the properties of erythrocytes as drug carriers, various methods for loading drugs into erythrocytes, factors affecting the efficacy of erythrocyte-based drug delivery (such as the source of erythrocytes and the use of anticoagulants), advantages of this delivery system compared to others, and a range of potential applications.
What are the objectives of this text?
The text aims to provide a detailed overview of erythrocyte-based drug delivery systems. It seeks to examine the feasibility and advantages of using erythrocytes for targeted drug delivery, highlighting the methodologies involved and the factors that influence their success.
What are the different chapters covered in this text?
The text includes chapters on: Introduction; Source of erythrocytes; Isolation of erythrocytes; Drug loading in erythrocytes; Factors effecting resealed erythrocytes; Advantages of erythrocytes; Method of drug loading; In vitro characterization of erythrocytes; and Applications.
What are the sources of erythrocytes discussed?
The text mentions various mammalian sources of erythrocytes used in drug loading and delivery, including those from mice, cattle, pigs, dogs, sheep, goats, monkeys, chickens, rats, and rabbits. The use of anticoagulants like EDTA or heparin is also discussed.
What methods of drug loading into erythrocytes are discussed?
While specific methods aren't detailed in the provided preview, the text indicates that different methods of drug loading are explored within the full document.
What are the advantages of using erythrocytes for drug delivery?
The advantages of using erythrocytes for drug delivery are discussed in a dedicated chapter, though the specifics are not given in this preview.
What are the potential applications of erythrocyte-based drug delivery systems?
The potential applications of erythrocyte-based drug delivery are explored in the final chapter of the text. However, the specific applications are not detailed in this preview.
What are the key words associated with this text?
Key words include: Erythrocytes, red blood cells, drug delivery, targeted drug delivery, drug loading, resealing, mammalian erythrocytes, anticoagulants, in vitro characterization, and applications.
What is the target audience for this text?
Given its academic nature and focus on detailed methodologies and analysis, the target audience is likely researchers and professionals in the fields of pharmacology, biomedical engineering, and related disciplines.
- Quote paper
- M.Pharm Sonam Gandhi (Author), 2017, Resealed Erythrocytes, Munich, GRIN Verlag, https://www.grin.com/document/419060
