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Meta-analysis of the association of NRXN1 variants and Psychotic Spectrum Disorders

Title: Meta-analysis of the association of NRXN1 variants and Psychotic Spectrum Disorders

Academic Paper , 2017 , 62 Pages

Autor:in: Pedro Gurillo Muñoz (Author)

Medicine - Neurology, Psychiatry, Addiction
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Summary Excerpt Details

Objective: To perform a meta-analysis of all published genetic association studies of NRNX1 variants and psychotic spectrum disorders (PSD).

Methods: Potential studies were identified through PubMed/MEDLINE, EMBASE, HuGeNet, GeneCard and WoS up from 1980 until June 2015 (week 5). Published observational studies reporting NRXN1 variants in PSD cases and in non-PSD controls were all considered eligible for inclusion in this systematic review. Two reviewers selected studies for possible inclusion and extracted data independently following a standardized protocol. Different meta-analyses were performed for each NRXN1 variant and PSD and controls, with a random-effect model to calculate the pooled OR and its corresponding 95% CI. Forest plots and Cochran’s Q-Statistic and I2 index were calculated to check for heterogeneity. Subgroup analyses and chi-square test were carried out to analyze potential moderators. Publication bias and quality of reporting were also analyzed.

Results: 19 studies met our inclusion criteria, providing a total sample of 25208 patients with PSD and 56971 controls. Meta-analyses of NRXN1 deletions (OR = 3.36), exons (OR = 3.53) and introns (OR = 2.02) showed evidence of an association between NRXN1 gene and PSD. Only one study influed in a meta-analysis (NRXN1 deletions) and no quality criterion affected as moderating variable. There was evidence of potential publication bias in NRXN1 deletions, exonic and promoter meta-analyses.

Conclusions: We found association between some variants of the NRXN1 gene and PSD. It´s important to develop a greater effort for the study of the NRXN1 gene and bigger number of studies that will clarify it´s association.

The appendix is in Spanish.

Excerpt


Inhaltsverzeichnis (Table of Contents)

  • Abstract
  • Background
  • Methods
    • Search strategy
    • Inclusion and exclusion criteria
    • Data extraction
    • Quality of the studies
    • Statistical analysis
  • Results
    • Meta-analysis of association of the NRXN1 variants with PSD
    • Sensitivity analysis
    • Quality of studies...
    • Publication bias...
    • NRXN1 deletions
    • NRXN1 duplications.......
    • NRXN1 polimorphisms
      • NRXN1 coding region (exon)
      • NRXN1 no coding region (intron)
      • NRXN1 promoter region........
  • Discussion......
  • Conclusions
  • References
  • Supplementary Matherial
    • Supplementary Figures..
    • Supplementary Tables
  • Appendix
    • I. Introducción
    • II. Variables
    • III. Análisis unitario....
    • IV. Explicación de variables
    • V. Variables de sujeto .......
    • VI. Variables de la enfermedad
    • VII. Características del marcador genético.
    • VIII. Variables metodológicas.
    • IX. Variables resultado

Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)

This study aims to conduct a comprehensive meta-analysis of all published genetic association studies investigating the relationship between variants of the NRXN1 gene and psychotic spectrum disorders (PSD). The study uses a systematic approach to identify relevant studies, extract data, and perform meta-analysis to assess the strength of association between NRXN1 variants and PSD.

  • Association between NRXN1 variants and PSD
  • Impact of different NRXN1 variants on PSD risk
  • Exploration of potential moderators of the association
  • Assessment of publication bias and quality of reporting
  • Implications for understanding the genetic basis of PSD

Zusammenfassung der Kapitel (Chapter Summaries)

  • Abstract: The abstract outlines the study's objectives, methods, results, and conclusions. It highlights the association found between NRXN1 variants and PSD, emphasizing the need for further research.
  • Background: This section provides an overview of schizophrenia and its prevalence, emphasizing the role of aberrant synaptic connectivity in the neuropathology of schizophrenia. It cites existing research findings suggesting a link between NRXN1 gene mutations and schizophrenia.
  • Methods: The study details the systematic approach employed, including the search strategy, inclusion and exclusion criteria, data extraction methods, quality assessment, and statistical analysis techniques.
  • Results: This section presents the results of the meta-analysis, including findings on NRXN1 deletions, exons, and introns. It discusses potential moderators and publication bias.

Schlüsselwörter (Keywords)

The study focuses on NRXN1, neurexin 1, 2p16.3, meta-analysis, schizophrenia, psychotic disorder, schizoaffective disorder, psychosis. The research delves into the genetic association between NRXN1 variants and PSD, providing valuable insights into the genetic underpinnings of these complex disorders.

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Details

Title
Meta-analysis of the association of NRXN1 variants and Psychotic Spectrum Disorders
College
University of Murcia
Author
Pedro Gurillo Muñoz (Author)
Publication Year
2017
Pages
62
Catalog Number
V439368
ISBN (eBook)
9783668800182
ISBN (Book)
9783668800199
Language
English
Tags
meta-analysis nrxn1 neurexin 1 2p16.3 schizophrenia psychotic disorder schizoaffective disorder psychosis
Product Safety
GRIN Publishing GmbH
Quote paper
Pedro Gurillo Muñoz (Author), 2017, Meta-analysis of the association of NRXN1 variants and Psychotic Spectrum Disorders, Munich, GRIN Verlag, https://www.grin.com/document/439368
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