Objective: To perform a meta-analysis of all published genetic association studies of NRNX1 variants and psychotic spectrum disorders (PSD).
Methods: Potential studies were identified through PubMed/MEDLINE, EMBASE, HuGeNet, GeneCard and WoS up from 1980 until June 2015 (week 5). Published observational studies reporting NRXN1 variants in PSD cases and in non-PSD controls were all considered eligible for inclusion in this systematic review. Two reviewers selected studies for possible inclusion and extracted data independently following a standardized protocol. Different meta-analyses were performed for each NRXN1 variant and PSD and controls, with a random-effect model to calculate the pooled OR and its corresponding 95% CI. Forest plots and Cochran’s Q-Statistic and I2 index were calculated to check for heterogeneity. Subgroup analyses and chi-square test were carried out to analyze potential moderators. Publication bias and quality of reporting were also analyzed.
Results: 19 studies met our inclusion criteria, providing a total sample of 25208 patients with PSD and 56971 controls. Meta-analyses of NRXN1 deletions (OR = 3.36), exons (OR = 3.53) and introns (OR = 2.02) showed evidence of an association between NRXN1 gene and PSD. Only one study influed in a meta-analysis (NRXN1 deletions) and no quality criterion affected as moderating variable. There was evidence of potential publication bias in NRXN1 deletions, exonic and promoter meta-analyses.
Conclusions: We found association between some variants of the NRXN1 gene and PSD. It´s important to develop a greater effort for the study of the NRXN1 gene and bigger number of studies that will clarify it´s association.
The appendix is in Spanish.
Inhaltsverzeichnis (Table of Contents)
- Abstract
- Background
- Methods
- Search strategy
- Inclusion and exclusion criteria
- Data extraction
- Quality of the studies
- Statistical analysis
- Results
- Meta-analysis of association of the NRXN1 variants with PSD
- Sensitivity analysis
- Quality of studies...
- Publication bias...
- NRXN1 deletions
- NRXN1 duplications.......
- NRXN1 polimorphisms
- NRXN1 coding region (exon)
- NRXN1 no coding region (intron)
- NRXN1 promoter region........
- Discussion......
- Conclusions
- References
- Supplementary Matherial
- Supplementary Figures..
- Supplementary Tables
- Appendix
- I. Introducción
- II. Variables
- III. Análisis unitario....
- IV. Explicación de variables
- V. Variables de sujeto .......
- VI. Variables de la enfermedad
- VII. Características del marcador genético.
- VIII. Variables metodológicas.
- IX. Variables resultado
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This study aims to conduct a comprehensive meta-analysis of all published genetic association studies investigating the relationship between variants of the NRXN1 gene and psychotic spectrum disorders (PSD). The study uses a systematic approach to identify relevant studies, extract data, and perform meta-analysis to assess the strength of association between NRXN1 variants and PSD.
- Association between NRXN1 variants and PSD
- Impact of different NRXN1 variants on PSD risk
- Exploration of potential moderators of the association
- Assessment of publication bias and quality of reporting
- Implications for understanding the genetic basis of PSD
Zusammenfassung der Kapitel (Chapter Summaries)
- Abstract: The abstract outlines the study's objectives, methods, results, and conclusions. It highlights the association found between NRXN1 variants and PSD, emphasizing the need for further research.
- Background: This section provides an overview of schizophrenia and its prevalence, emphasizing the role of aberrant synaptic connectivity in the neuropathology of schizophrenia. It cites existing research findings suggesting a link between NRXN1 gene mutations and schizophrenia.
- Methods: The study details the systematic approach employed, including the search strategy, inclusion and exclusion criteria, data extraction methods, quality assessment, and statistical analysis techniques.
- Results: This section presents the results of the meta-analysis, including findings on NRXN1 deletions, exons, and introns. It discusses potential moderators and publication bias.
Schlüsselwörter (Keywords)
The study focuses on NRXN1, neurexin 1, 2p16.3, meta-analysis, schizophrenia, psychotic disorder, schizoaffective disorder, psychosis. The research delves into the genetic association between NRXN1 variants and PSD, providing valuable insights into the genetic underpinnings of these complex disorders.
- Citation du texte
- Pedro Gurillo Muñoz (Auteur), 2017, Meta-analysis of the association of NRXN1 variants and Psychotic Spectrum Disorders, Munich, GRIN Verlag, https://www.grin.com/document/439368
