Gliomas are the most common type of human brain cancers and make up a third of all tumours of the central nervous system. Mutations in the IDH-gene are frequent and regarded as an early event in gliomagenesis. IDH mutations are considered to be associated with better outcome. If this accounts for all histological subtypes and for low as well as for high grade gliomas has yet to be clarified. The aim of this paper is to present recent evidence on the question of whether mutations of the IDH-gene affect the outcome of patients with glioma/glioblastoma.
For this, electronic databases were searched for studies published after 2008, which yielded 1160 articles. The quality of the studies was critically evaluated. Overall Survival, Progression Free Survival and their p-values were analysed to assess the relation between IDH mutation and outcome. The results were extracted, analysed and compared to gain a thorough overview of the current evidence base.
Inhaltsverzeichnis (Table of Contents)
- Introduction
- Aim
- Methods
- Results
- Conclusion
- Acknowledgements
- My Contribution
- Search strategy and study selection
Zielsetzung und Themenschwerpunkte (Objectives and Key Themes)
This systematic review aims to examine the relationship between IDH mutations and the outcome of patients diagnosed with glioma or glioblastoma. The review focuses on recent evidence from studies published after 2008 to determine if IDH mutations impact overall survival and progression-free survival in patients with these brain tumors.
- Impact of IDH mutations on glioma/glioblastoma outcome
- Influence of IDH mutations on survival rates in different glioma subtypes
- Relationship between IDH mutations and histological characteristics
- Role of genetic parameters in predicting glioma prognosis
- Analysis of complete resection and its correlation with IDH mutations
Zusammenfassung der Kapitel (Chapter Summaries)
- Introduction: Provides background information on gliomas, their prevalence, and the significance of IDH mutations in gliomagenesis. The introduction outlines the importance of understanding the impact of IDH mutations on patient outcomes.
- Aim: Clearly states the purpose of the systematic review, which is to investigate the relationship between IDH mutations and outcome in patients with glioma/glioblastoma.
- Methods: Details the methodology employed in conducting the review. This includes the search strategy used to identify relevant studies, the criteria for inclusion and exclusion of studies, and the methods for data extraction and analysis.
- Results: Presents the findings of the systematic review. This section discusses the results of the analysis of the included studies and provides evidence on the association between IDH mutations and various aspects of patient outcome, including overall survival, progression-free survival, and complete resection.
- Conclusion: Summarizes the main findings of the systematic review and discusses the implications of the results. This section offers insights into the role of IDH mutations in glioma/glioblastoma outcomes and highlights areas for further research.
- Acknowledgements: Expresses gratitude to individuals and institutions who contributed to the research and provided support.
- My Contribution: Reflects on the author's personal learning experiences during the research process, including challenges encountered and strategies for overcoming them.
- Search strategy and study selection: Describes the detailed process involved in developing a search strategy, selecting relevant studies, and ensuring a comprehensive review of the existing literature.
Schlüsselwörter (Keywords)
The primary focus of this systematic review is on the impact of IDH mutations on the outcome of patients with gliomas, particularly glioblastoma (GBM), oligodendroglioma, and astrocytoma. Key themes include overall survival, progression-free survival, and the role of other genetic markers in influencing prognosis. The review considers the influence of IDH mutations on various histological subtypes of gliomas and explores the relationship between IDH mutations and complete resection.
- Arbeit zitieren
- Ronja Handwerker (Autor:in), 2018, Review of therapy response and survival of patients with glioma or glioblastoma and IDH mutation, München, GRIN Verlag, https://www.grin.com/document/465476
