Résumé ou Introduction
Seminar Presentation in the subject "Inorganic Chemistry" with the title "Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents". With the following contents:
-The problems of the currently used anticancer drugs;
- Palladium derivatives as an alternative to Platinum-based compounds;
- The first Water-Soluble Iminophosphorane Ligand;
- Preparation of Water-Soluble Ligand 1;
- Stability of Compounds in Solution;
- Cytotoxicity IC50 (μM) of Cisplatin, Ligand 1, Phosphine Oxide, TPA=O, and Metal Complexes 2-8 in Human cell lines;
- The Annexin V Binding Assay;
- Activity of Compounds 2 or 3 (50 μM) and Cisplatin against apoptosis-resistent cells;
- Chromosomal DNA and Plasmid DNA;
- Interactions of 2 and 3 with Plasmid DNA Using Electroforesis Mobility Shift Assay (EMSA);
- Interaction with Human Serum Albumin;
- Stern-Volmer plot for quenching with ligand 1 and compounds 2, 3, and 5 – 8 and cisplatin;
- Advantage over Cisplatin;
- Summery
- Citation du texte
- Sadik Mejid (Auteur), 2014, Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents, Munich, GRIN Verlag, https://www.grin.com/document/475220
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