Gliomas are the most common type of human brain cancers and make up a third of all tumours of the central nervous system. Mutations in the IDH-gene are frequent and regarded as an early event in gliomagenesis. IDH mutations are considered to be associated with better outcome. If this accounts for all histological subtypes and for low as well as for high grade gliomas has yet to be clarified. The aim of this paper is to present recent evidence on the question of whether mutations of the IDH-gene affect the outcome of patients with glioma/glioblastoma.
For this, electronic databases were searched for studies published after 2008, which yielded 1160 articles. The quality of the studies was critically evaluated. Overall Survival, Progression Free Survival and their p-values were analysed to assess the relation between IDH mutation and outcome. The results were extracted, analysed and compared to gain a thorough overview of the current evidence base.
Contents
Introduction
Definition Gliomas and Glioblastomas
Isocitratdehydrogenase- Gene & the Enzyme IDH
Epidemiology and Prognosis
Cell of origin, Epigenetics & Genetic Pathways of Tumorigenesis
Treatment Implications of IDH
Indications for a Systematic Review
Aims
Methodology
Research Question
Databases
Search strategy
Study Selection
Eligibility criteria
Inclusion criteria
Exclusion criteria
Study Analysis/ Quality Assessment
Results
Search results
Study and participant characteristics
Analysis of Data & Discussion
Conclusion
References
Appendices
Appendix 1- the Search Strategy
Appendix 2- PRISMA flowchart
Appendix 3- Quality Assessment
A) Newcastle-Ottawa Scale
B) CASP-Tool
Appendix 4- Results-Table
Figures
Figure 1 — Diffuse Gliomas: from histology, IDH status and other genetic parameters
Figure 2 - Potential mechanism implicated in tumorigenesis induced by IDH MUTATION
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